Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism

Hepatocyte inducible nitric oxide synthese (iNOS) expression is a tightly controlled pathway that mediates hepatic inflammation and hepatocyte injury in a variety of disease states. We have shown that cyclic adenosine monophosphate (cAMP) regulates cytokine-induced hepatocyte iNOS expression through...

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Bibliographic Details
Main Authors: Harbrecht, Brian G., Nweze, Ikenna, Smith, Jason W., Zhang, Baochun
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Hormones and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345958/
https://ncbi.nlm.nih.gov/pubmed/22038823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00114.2011
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