Calcium-mediated signaling and calmodulin-dependent kinase regulate hepatocyte inducible nitric oxide synthase expression

BACKGROUND: Nitric oxide synthase (iNOS) is induced in hepatocytes by shock and inflammatory stimuli. Excessive NO from iNOS mediates shock-induced hepatic injury and death so understanding the regulation of iNOS will help elucidate the pathophysiology of septic shock. In vitro, cytokines induce iNO...

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Udgivet i:J Surg Res
Main Authors: Zhang, Baochun, Crankshaw, Will, Nesemeier, Ryan, Patel, Jay, Nweze, Ikenna, Lakshmanan, Jaganathan, Harbrecht, Brian G.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268076/
https://ncbi.nlm.nih.gov/pubmed/25150084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2014.07.042
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