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ACTIVATION OF A CYCLIC AMP-GUANINE EXCHANGE FACTOR IN HEPATOCYTES DECREASES NITRIC OXIDE SYNTHASE EXPRESSION

Adenosine 3′, 5′-cyclic adenosine monophosphate (cAMP) activates intracellular signaling by regulating Protein Kinase A (PKA), calcium influx, and cAMP-binging guanine nucleotide exchange factors (Epac or cAMP-GEF). cAMP inhibits cytokine-induced expression of nitric oxide synthase (iNOS) in hepatoc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Baochun, Nweze, Ikenna, Lakshmanan, Jaganathan, Harbrecht, Brian G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526687/
https://ncbi.nlm.nih.gov/pubmed/23143065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e3182760530
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