CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

Extracellular adenosine (ADO), generated from ATP or ADP through the concerted action of the ectoenzymes CD39 and CD73, elicits autocrine and paracrine effects mediated by type 1 purinergic receptors. We have tested whether the expression of CD39 and CD73 by chronic lymphocytic leukemia (CLL) cells...

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Autori principali: Serra, Sara, Horenstein, Alberto L., Vaisitti, Tiziana, Brusa, Davide, Rossi, Davide, Laurenti, Luca, D'Arena, Giovanni, Coscia, Marta, Tripodo, Claudio, Inghirami, Giorgio, Robson, Simon C., Gaidano, Gianluca, Malavasi, Fabio, Deaglio, Silvia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2011
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342854/
https://ncbi.nlm.nih.gov/pubmed/21998208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-374728
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