The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia

Chronic lymphocytic leukemia is marked by profound defects in T-cell function. Programmed death-1 is a receptor involved in tumor-mediated immunosuppression through binding of the PD-L1 ligand. Multiparametric flow cytometry and immunohistochemistry were used to study PD-1/PD-L1 expression. Function...

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Hlavní autoři: Brusa, Davide, Serra, Sara, Coscia, Marta, Rossi, Davide, D’Arena, Giovanni, Laurenti, Luca, Jaksic, Ozren, Fedele, Giorgio, Inghirami, Giorgio, Gaidano, Gianluca, Malavasi, Fabio, Deaglio, Silvia
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2013
Témata:
Original Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669453/
https://ncbi.nlm.nih.gov/pubmed/23300177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.077537
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