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Defect of Adaptation to Hypoxia in Patients With COPD Due to Reduction of Histone Deacetylase 7
BACKGROUND: Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin. Sputum VEGF levels are reported to be decreased in COPD, despite hypoxia. Here we show tha...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American College of Chest Physicians
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3342783/ https://ncbi.nlm.nih.gov/pubmed/22172637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.11-1536 |
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