Defect of Adaptation to Hypoxia in Patients With COPD Due to Reduction of Histone Deacetylase 7

BACKGROUND: Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin. Sputum VEGF levels are reported to be decreased in COPD, despite hypoxia. Here we show tha...

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Hauptverfasser: To, Masako, Yamamura, Satoshi, Akashi, Kenichi, Charron, Catherine E., Barnes, Peter J., Ito, Kazuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American College of Chest Physicians 2012
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342783/
https://ncbi.nlm.nih.gov/pubmed/22172637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.11-1536
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