Hypoxia-inducible Factor 1α Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription

Corticosteroids are potent anti-inflammatory agents, but corticosteroid insensitivity is a major barrier for the treatment of some chronic inflammatory diseases. Here, we show that hypoxia induces corticosteroid-insensitive inflammation via reduced transcription of histone deacetylase-2 (HDAC2) in l...

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Bibliographic Details
Main Authors: Charron, Catherine E., Chou, Pai-Chien, Coutts, David J. C., Kumar, Vaibhav, To, Masako, Akashi, Kenichi, Pinhu, Liao, Griffiths, Mark, Adcock, Ian M., Barnes, Peter J., Ito, Kazuhiro
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Transcription, Chromatin, and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794720/
https://ncbi.nlm.nih.gov/pubmed/19880520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025387
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