Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase that Employs Acyl-ACP as a Starter Unit Donor

Germicidin synthase (Gcs) from Streptomyces coelicolor is a type III polyketide synthase (PKS) with broad substrate flexibility for acyl groups linked through a thioester bond to either coenzyme A (CoA) or acyl carrier protein (ACP). Germicidin synthesis was reconstituted in vitro by coupling Gcs wi...

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Hauptverfasser: Chemler, Joseph A., Buchholz, Tonia J., Geders, Todd W., Akey, David L., Rath, Christopher M., Chlipala, George E., Smith, Janet L., Sherman, David H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342439/
https://ncbi.nlm.nih.gov/pubmed/22480290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2112228
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