Polyketide β-Branching in Bryostatin Biosynthesis: Identification of Surrogate Acetyl-ACP Donors for BryR, an HMG-ACP Synthase

In vitro analysis of natural product biosynthetic gene products isolated from unculturable symbiotic bacteria is necessary to probe the functionalities of these enzymes. Herein, we report the biochemical characterization of BryR, the 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase (HMGS) homolog impli...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Buchholz, Tonia J., Rath, Christopher M., Lopanik, Nicole B., Gardner, Noah P., Håkansson, Kristina, Sherman, David H.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990979/
https://ncbi.nlm.nih.gov/pubmed/21035732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.08.008
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires