Polyketide β-Branching in Bryostatin Biosynthesis: Identification of Surrogate Acetyl-ACP Donors for BryR, an HMG-ACP Synthase

In vitro analysis of natural product biosynthetic gene products isolated from unculturable symbiotic bacteria is necessary to probe the functionalities of these enzymes. Herein, we report the biochemical characterization of BryR, the 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase (HMGS) homolog impli...

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Detalhes bibliográficos
Main Authors: Buchholz, Tonia J., Rath, Christopher M., Lopanik, Nicole B., Gardner, Noah P., Håkansson, Kristina, Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990979/
https://ncbi.nlm.nih.gov/pubmed/21035732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.08.008
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