Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

Forkhead box class O 3a (FOXO3a) is a transcription factor and tumor suppressor linked to longevity that determines cell fate through activating transcription of cell differentiation, survival, and apoptotic genes. Recruitment of the coactivator CBP/p300 is a crucial step in transcription, and we re...

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Hlavní autoři: Wang, Feng, Marshall, Christopher B., Yamamoto, Kazuo, Li, Guang-Yao, Gasmi-Seabrook, Geneviève M. C., Okada, Hitoshi, Mak, Tak W., Ikura, Mitsuhiko
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341034/
https://ncbi.nlm.nih.gov/pubmed/22474372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119073109
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