Leu628 of the KIX Domain of CBP is a Key Residue for the Interaction with the MLL Transactivation Domain

Physical interaction between the transactivation domain (TAD) of the mixed-lineage leukemia protein (MLL) and the KIX domain of the CREB binding protein (CBP) is necessary for MLL-mediated transcriptional activation. We show by alanine-scanning mutagenesis that hydrophobic surface residues of KIX, e...

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Hlavní autoři: Arai, Munehito, Dyson, H. Jane, Wright, Peter E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993637/
https://ncbi.nlm.nih.gov/pubmed/20969867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.10.024
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