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Leu628 of the KIX Domain of CBP is a Key Residue for the Interaction with the MLL Transactivation Domain
Physical interaction between the transactivation domain (TAD) of the mixed-lineage leukemia protein (MLL) and the KIX domain of the CREB binding protein (CBP) is necessary for MLL-mediated transcriptional activation. We show by alanine-scanning mutagenesis that hydrophobic surface residues of KIX, e...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993637/ https://ncbi.nlm.nih.gov/pubmed/20969867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.10.024 |
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