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Quantitative analysis of multisite protein ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP
Determination of affinities and binding sites involved in protein-ligand interactions is essential for understanding molecular mechanisms in biological systems. Here we combine singular value decomposition, and global analysis of NMR chemical shift perturbations caused by protein-protein interaction...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290704/ https://ncbi.nlm.nih.gov/pubmed/22280219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209936u |
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