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Quantitative analysis of multisite protein ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP

Determination of affinities and binding sites involved in protein-ligand interactions is essential for understanding molecular mechanisms in biological systems. Here we combine singular value decomposition, and global analysis of NMR chemical shift perturbations caused by protein-protein interaction...

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Detaylı Bibliyografya
Asıl Yazarlar: Arai, Munehito, Ferreon, Josephine C., Wright, Peter E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290704/
https://ncbi.nlm.nih.gov/pubmed/22280219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209936u
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