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Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2
The tumor suppressor activity of p53 is regulated by interactions with the ubiquitin ligase HDM2 and the general transcriptional coactivators CBP and p300. Using NMR spectroscopy and isothermal titration calorimetry, we have dissected the binding interactions between the N-terminal transactivation d...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2672497/ https://ncbi.nlm.nih.gov/pubmed/19357310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811023106 |
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