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Structure of the p53 transactivation domain in complex with the nuclear coactivator binding domain of CBP
The activity and stability of the tumor suppressor p53 is regulated by interactions with key cellular proteins such as MDM2 and CBP/p300. The transactivation domain (TAD) of p53 contains two subdomains (AD1 and AD2) and interacts directly with the N-terminal domain of MDM2 and with several domains o...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2982890/ https://ncbi.nlm.nih.gov/pubmed/20961098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1012996 |
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