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Structure of the p53 transactivation domain in complex with the nuclear coactivator binding domain of CBP

The activity and stability of the tumor suppressor p53 is regulated by interactions with key cellular proteins such as MDM2 and CBP/p300. The transactivation domain (TAD) of p53 contains two subdomains (AD1 and AD2) and interacts directly with the N-terminal domain of MDM2 and with several domains o...

詳細記述

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書誌詳細
主要な著者: Lee, Chul Won, Martinez-Yamout, Maria A., Dyson, H. Jane, Wright, Peter E.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982890/
https://ncbi.nlm.nih.gov/pubmed/20961098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1012996
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