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Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers

Thyroid hormones such as 3,3′,5 triiodo-l-thyronine (T3) control numerous aspects of mammalian development and metabolism. The actions of such hormones are mediated by specific thyroid hormone receptors (TRs). TR belongs to the nuclear receptor family of modular transcription factors that binds to s...

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Bibliografske podrobnosti
Main Authors: Putcha, Balananda-Dhurjati K., Wright, Edward, Brunzelle, Joseph S., Fernandez, Elias J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341017/
https://ncbi.nlm.nih.gov/pubmed/22474364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119852109
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