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Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers

Thyroid hormones such as 3,3′,5 triiodo-l-thyronine (T3) control numerous aspects of mammalian development and metabolism. The actions of such hormones are mediated by specific thyroid hormone receptors (TRs). TR belongs to the nuclear receptor family of modular transcription factors that binds to s...

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Библиографические подробности
Главные авторы: Putcha, Balananda-Dhurjati K., Wright, Edward, Brunzelle, Joseph S., Fernandez, Elias J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341017/
https://ncbi.nlm.nih.gov/pubmed/22474364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119852109
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