Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state

Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets and function in postmitotic cells remain poorly understood. Here we show that a switch in the expression from Topoisomerases IIα (Top2α) to IIβ (Top2β) occurs during neuronal differentiation in vitro and in...

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Main Authors: Tiwari, Vijay K., Burger, Lukas, Nikoletopoulou, Vassiliki, Deogracias, Ruben, Thakurela, Sudhir, Wirbelauer, Christiane, Kaut, Johannes, Terranova, Remi, Hoerner, Leslie, Mielke, Christian, Boege, Fritz, Murr, Rabih, Peters, Antoine H. F. M., Barde, Yves-Alain, Schübeler, Dirk
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340998/
https://ncbi.nlm.nih.gov/pubmed/22474351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119798109
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