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DNA Sequence Explains Seemingly Disordered Methylation Levels in Partially Methylated Domains of Mammalian Genomes

For the most part metazoan genomes are highly methylated and harbor only small regions with low or absent methylation. In contrast, partially methylated domains (PMDs), recently discovered in a variety of cell lines and tissues, do not fit this paradigm as they show partial methylation for large por...

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Autores principales: Gaidatzis, Dimos, Burger, Lukas, Murr, Rabih, Lerch, Anita, Dessus-Babus, Sophie, Schübeler, Dirk, Stadler, Michael B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923675/
https://ncbi.nlm.nih.gov/pubmed/24550741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004143
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