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Genome-wide Single-Molecule Footprinting Reveals High RNA Polymerase II Turnover at Paused Promoters

Transcription initiation entails chromatin opening followed by pre-initiation complex formation and RNA polymerase II recruitment. Subsequent polymerase elongation requires additional signals, resulting in increased residence time downstream of the start site, a phenomenon referred to as pausing. He...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Krebs, Arnaud R., Imanci, Dilek, Hoerner, Leslie, Gaidatzis, Dimos, Burger, Lukas, Schübeler, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548954/
https://ncbi.nlm.nih.gov/pubmed/28735898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.027
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