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Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation

Trimethylation of histone H3 at lysine 27 (H3K27me3) is a chromatin mark associated with Polycomb-mediated gene repression. Despite its critical role in development, it remains largely unclear how this mark is targeted to defined loci in mammalian cells. Here, we use iterative genome editing to iden...

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Autori principali: Jermann, Philip, Hoerner, Leslie, Burger, Lukas, Schübeler, Dirk
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143037/
https://ncbi.nlm.nih.gov/pubmed/25092339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400672111
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