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Transcription-Coupled Methylation of Histone H3 at Lysine 36 Regulates Dosage Compensation by Enhancing Recruitment of the MSL Complex in Drosophila melanogaster

In Drosophila melanogaster, dosage compensation relies on the targeting of the male-specific lethal (MSL) complex to hundreds of sites along the male X chromosome. Transcription-coupled methylation of histone H3 lysine 36 is enriched toward the 3′ end of active genes, similar to the MSL proteins. He...

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Detalhes bibliográficos
Main Authors: Bell, Oliver, Conrad, Thomas, Kind, Jop, Wirbelauer, Christiane, Akhtar, Asifa, Schübeler, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423169/
https://ncbi.nlm.nih.gov/pubmed/18347056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00006-08
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