Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state

Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets and function in postmitotic cells remain poorly understood. Here we show that a switch in the expression from Topoisomerases IIα (Top2α) to IIβ (Top2β) occurs during neuronal differentiation in vitro and in...

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Detalhes bibliográficos
Main Authors: Tiwari, Vijay K., Burger, Lukas, Nikoletopoulou, Vassiliki, Deogracias, Ruben, Thakurela, Sudhir, Wirbelauer, Christiane, Kaut, Johannes, Terranova, Remi, Hoerner, Leslie, Mielke, Christian, Boege, Fritz, Murr, Rabih, Peters, Antoine H. F. M., Barde, Yves-Alain, Schübeler, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340998/
https://ncbi.nlm.nih.gov/pubmed/22474351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119798109
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