The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury

Inhibition of the tumor suppressor p53 diminishes tubular cell apoptosis and protects renal function in animal models of acute kidney injury (AKI). Therefore, targeting p53 has become an attractive therapeutic strategy in the approach to AKI. Although the acute protective effects of p53 inhibition i...

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Main Authors: Dagher, Pierre C., Mai, Erik M., Hato, Takashi, Lee, So-Young, Anderson, Melissa D., Karozos, Stephanie C., Mang, Henry E., Knipe, Nicole L., Plotkin, Zoya, Sutton, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340920/
https://ncbi.nlm.nih.gov/pubmed/22049400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00317.2011
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