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Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury

Ischemic injury to the kidney is characterized in part by nucleotide depletion and tubular cell death in the form of necrosis or apoptosis. Recently, we linked anoxia-induced apoptosis in renal cell cultures specifically to the depletion of GTP. We therefore hypothesized that enhancing GTP repletion...

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Detalhes bibliográficos
Main Authors: Kelly, K.J., Plotkin, Zoya, Dagher, Pierre C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC209442/
https://ncbi.nlm.nih.gov/pubmed/11696573
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