p53 Is Renoprotective after Ischemic Kidney Injury by Reducing Inflammation

In the rat, p53 promotes tubular apoptosis after ischemic AKI. Acute pharmacologic inhibition of p53 is protective in this setting, but chronic inhibition enhances fibrosis, demonstrating that the role of p53 in ischemic AKI is incompletely understood. Here, we investigated whether genetic absence o...

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Detalhes bibliográficos
Main Authors: Sutton, Timothy A., Hato, Takashi, Mai, Erik, Yoshimoto, Momoko, Kuehl, Sarah, Anderson, Melissa, Mang, Henry, Plotkin, Zoya, Chan, Rebecca J., Dagher, Pierre C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537213/
https://ncbi.nlm.nih.gov/pubmed/23222126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012050469
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