Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury

The development of chronic kidney disease (CKD) following an episode of acute kidney injury (AKI) is an increasingly recognized clinical problem. Inhibition of toll-like receptor 4 (TLR4) protects renal function in animal models of AKI and has become a viable therapeutic strategy in AKI. However, th...

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Udgivet i:Int J Mol Sci
Main Authors: Dagher, Pierre C., Hato, Takashi, Mang, Henry E., Plotkin, Zoya, Richardson, Quentin V., Massad, Michael, Mai, Erik, Kuehl, Sarah E., Graham, Paige, Kumar, Rakesh, Sutton, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881473/
https://ncbi.nlm.nih.gov/pubmed/27136544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17050647
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