p53 regulates renal expression of HIF-1α and pVHL under physiological conditions and after ischemia-reperfusion injury

Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and is characterized by widespread tubular and microvascular damage. The tumor suppressor p53 is upregulated after IRI and contributes to renal injury in part by promoting apoptosis. Acute, short-term inhibition of p53...

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Main Authors: Sutton, Timothy A., Wilkinson, Jared, Mang, Henry E., Knipe, Nicole L., Plotkin, Zoya, Hosein, Maya, Zak, Katelyn, Wittenborn, Jeremy, Dagher, Pierre C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604829/
https://ncbi.nlm.nih.gov/pubmed/18815219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90304.2008
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