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Nur77 upregulates HIF-α by inhibiting pVHL-mediated degradation
In this study, we investigated the role of Nur77, an orphan nuclear receptor, in HIF-α transcriptional activity. We found that Nur77 associates and stabilizes HIF-1α via indirect interaction. Nur77 was found to interact with pVHL in vivo via the α-domain of pVHL. By binding to pVHL, Nur77 competed w...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Korean Society of Medical Biochemistry and Molecular Biology
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2679322/ https://ncbi.nlm.nih.gov/pubmed/18305400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2008.40.1.71 |
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