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Nur77 upregulates HIF-α by inhibiting pVHL-mediated degradation

In this study, we investigated the role of Nur77, an orphan nuclear receptor, in HIF-α transcriptional activity. We found that Nur77 associates and stabilizes HIF-1α via indirect interaction. Nur77 was found to interact with pVHL in vivo via the α-domain of pVHL. By binding to pVHL, Nur77 competed w...

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Detalles Bibliográficos
Autores principales: Kim, Bu-Yeon, Kim, Hyungsoo, Cho, Eun-Jung, Youn, Hong-Duk
Formato: Artigo
Lenguaje:Inglês
Publicado: Korean Society of Medical Biochemistry and Molecular Biology 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679322/
https://ncbi.nlm.nih.gov/pubmed/18305400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2008.40.1.71
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