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Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL
von Hippel–Lindau (VHL) disease is a hereditary cancer syndrome caused by inherited mutations that inactivate the VHL tumour suppressor gene. The VHL locus encodes pVHL, whose best studied function is to bind to and down-regulate the hypoxia-inducible factor (HIF) family of oxygen-dependent transcri...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Publishing Ltd
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3229769/ https://ncbi.nlm.nih.gov/pubmed/21155973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2010.01238.x |
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