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O(6)-methylguanine-DNA methyltransferase in glioma therapy: Promise and problems

Gliomas are the most frequent adult primary brain tumor, and are invariably fatal. The most common diagnosis glioblastoma (GBM) afflicts 12,500 new patents in the U.S. annually, and has a median survival of approximately one year when treated with the current standard of care. Alkylating agents have...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Silber, John R., Bobola, Michael S., Blank, A., Chamberlain, Marc C.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340514/
https://ncbi.nlm.nih.gov/pubmed/22244911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2011.12.004
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