Runx2 Protein Stabilizes Hypoxia-inducible Factor-1α through Competition with von Hippel-Lindau Protein (pVHL) and Stimulates Angiogenesis in Growth Plate Hypertrophic Chondrocytes

The regulation of hypoxia-inducible factor-1α (HIF-1α) during endochondral bone formation is not fully understood. Here, we investigated the cross-talk between HIF-1α and Runt-related transcription factor 2 (Runx2) in the growth plate. Runx2 caused the accumulation of HIF-1α protein in ATDC5 chondro...

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Detalhes bibliográficos
Main Authors: Lee, Sun-Hee, Che, Xiangguo, Jeong, Jae-Hwan, Choi, Je-Yong, Lee, Young-Joo, Lee, Yong-Hee, Bae, Suk-Chul, Lee, You-Mie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340285/
https://ncbi.nlm.nih.gov/pubmed/22351759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340232
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