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VHL Mutations Linked to Type 2C von Hippel-Lindau Disease Cause Extensive Structural Perturbations in pVHL
pVHL (von Hippel-Lindau tumor suppressor protein) is the substrate recognition subunit of the CBC(VHL) ubiquitin ligase complex promoting the degradation of hypoxia-inducible factor subunits, HIF-1/2α. Mutational inactivation of pVHL causes the hereditary von Hippel-Lindau tumor syndrome, which pred...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667738/ https://ncbi.nlm.nih.gov/pubmed/19228690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809056200 |
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