Diverse Effects of Mutations in Exon II of the von Hippel-Lindau (VHL) Tumor Suppressor Gene on the Interaction of pVHL with the Cytosolic Chaperonin and pVHL-Dependent Ubiquitin Ligase Activity

We examined the biogenesis of the von Hippel-Lindau (VHL) tumor suppressor protein (pVHL) in vitro and in vivo. pVHL formed a complex with the cytosolic chaperonin containing TCP-1 (CCT or TRiC) en route to assembly with elongin B/C and the subsequent formation of the VCB-Cul2 ubiquitin ligase. Bloc...

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Bibliographische Detailangaben
Hauptverfasser: Hansen, William J., Ohh, Michael, Moslehi, Javid, Kondo, Keiichi, Kaelin, William G., Welch, William J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC135590/
https://ncbi.nlm.nih.gov/pubmed/11865071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.6.1947-1960.2002
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