Diverse Effects of Mutations in Exon II of the von Hippel-Lindau (VHL) Tumor Suppressor Gene on the Interaction of pVHL with the Cytosolic Chaperonin and pVHL-Dependent Ubiquitin Ligase Activity

We examined the biogenesis of the von Hippel-Lindau (VHL) tumor suppressor protein (pVHL) in vitro and in vivo. pVHL formed a complex with the cytosolic chaperonin containing TCP-1 (CCT or TRiC) en route to assembly with elongin B/C and the subsequent formation of the VCB-Cul2 ubiquitin ligase. Bloc...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Hansen, William J., Ohh, Michael, Moslehi, Javid, Kondo, Keiichi, Kaelin, William G., Welch, William J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135590/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11865071/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.6.1947-1960.2002
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