Diverse Effects of Mutations in Exon II of the von Hippel-Lindau (VHL) Tumor Suppressor Gene on the Interaction of pVHL with the Cytosolic Chaperonin and pVHL-Dependent Ubiquitin Ligase Activity

We examined the biogenesis of the von Hippel-Lindau (VHL) tumor suppressor protein (pVHL) in vitro and in vivo. pVHL formed a complex with the cytosolic chaperonin containing TCP-1 (CCT or TRiC) en route to assembly with elongin B/C and the subsequent formation of the VCB-Cul2 ubiquitin ligase. Bloc...

Cijeli opis

Bibliografski detalji

Izdano u:	Mol Cell Biol
Glavni autori:	Hansen, William J., Ohh, Michael, Moslehi, Javid, Kondo, Keiichi, Kaelin, William G., Welch, William J.
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis 2002
Teme:	Cell Growth and Development
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135590/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11865071/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.6.1947-1960.2002
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!