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The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis

pVHL, the product of von Hippel-Lindau (VHL) tumor suppressor gene, functions as the substrate recognition component of an E3-ubiquitin ligase complex that targets hypoxia inducible factor α (HIF-α) for ubiquitination and degradation. Besides HIF-α, pVHL also interacts with other proteins and has mu...

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Detalhes bibliográficos
Main Authors: Zhao, Wen-Ting, Zhou, Cheng-Fu, Li, Xue-Bing, Zhang, Yun-Fang, Fan, Li, Pelletier, Jerry, Fang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675594/
https://ncbi.nlm.nih.gov/pubmed/23612971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455121
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