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The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis
pVHL, the product of von Hippel-Lindau (VHL) tumor suppressor gene, functions as the substrate recognition component of an E3-ubiquitin ligase complex that targets hypoxia inducible factor α (HIF-α) for ubiquitination and degradation. Besides HIF-α, pVHL also interacts with other proteins and has mu...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675594/ https://ncbi.nlm.nih.gov/pubmed/23612971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455121 |
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