Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α

pVHL, the protein product of the von Hippel-Lindau (VHL) tumor suppressor gene, is a ubiquitin ligase that targets hypoxia-inducible factor α (HIF-α) for proteasomal degradation. Although HIF-α activation is necessary for VHL disease pathogenesis, constitutive activation of HIF-α alone did not induc...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Okumura, Fumihiko, Uematsu, Keiji, Byrne, Stuart D., Hirano, Mie, Joo-Okumura, Akiko, Nishikimi, Akihiko, Shuin, Taro, Fukui, Yoshinori, Nakatsukasa, Kunio, Kamura, Takumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907096/
https://ncbi.nlm.nih.gov/pubmed/27090638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00067-16
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