Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX(1) and OX(2) Receptors Identify Slow Kinetics of Agonist Activation

Intramolecular fluorescence resonance energy transfer (FRET) sensors able to detect changes in distance or orientation between the 3rd intracellular loop and C-terminal tail of the human orexin OX(1) and OX(2) G protein-coupled receptors following binding of agonist ligands were produced and express...

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Detalhes bibliográficos
Main Authors: Xu, Tian-Rui, Ward, Richard J., Pediani, John D., Milligan, Graeme
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340242/
https://ncbi.nlm.nih.gov/pubmed/22389503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334300
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