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Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX(1) and OX(2) Receptors Identify Slow Kinetics of Agonist Activation

Intramolecular fluorescence resonance energy transfer (FRET) sensors able to detect changes in distance or orientation between the 3rd intracellular loop and C-terminal tail of the human orexin OX(1) and OX(2) G protein-coupled receptors following binding of agonist ligands were produced and express...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xu, Tian-Rui, Ward, Richard J., Pediani, John D., Milligan, Graeme
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340242/
https://ncbi.nlm.nih.gov/pubmed/22389503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334300
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