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Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging

BACKGROUND AND PURPOSE: Many G protein-coupled receptors internalize following agonist binding. The studies were designed to identify novel means to effectively quantify this process using the orexin OX(1) receptor and the cannabinoid CB(1) receptor as exemplars. EXPERIMENTAL APPROACH: The human OX(...

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Détails bibliographiques
Auteurs principaux: Ward, Richard J, Pediani, John D, Milligan, Graeme
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058174/
https://ncbi.nlm.nih.gov/pubmed/21175569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01156.x
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