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Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging

BACKGROUND AND PURPOSE: Many G protein-coupled receptors internalize following agonist binding. The studies were designed to identify novel means to effectively quantify this process using the orexin OX(1) receptor and the cannabinoid CB(1) receptor as exemplars. EXPERIMENTAL APPROACH: The human OX(...

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Autors principals: Ward, Richard J, Pediani, John D, Milligan, Graeme
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058174/
https://ncbi.nlm.nih.gov/pubmed/21175569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01156.x
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