Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

QRS interval on the electrocardiogram reflects ventricular depolarization and conduction time, and is a risk factor for mortality, sudden death, and heart failure. We performed a genome-wide association meta-analysis in 40,407 European-descent individuals from 14 studies, with further genotyping in...

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Asıl Yazarlar: Sotoodehnia, Nona, Isaacs, Aaron, de Bakker, Paul I.W., Dörr, Marcus, Newton-Cheh, Christopher, Nolte, Ilja M., van der Harst, Pim, Müller, Martina, Eijgelsheim, Mark, Alonso, Alvaro, Hicks, Andrew A., Padmanabhan, Sandosh, Hayward, Caroline, Smith, Albert Vernon, Polasek, Ozren, Giovannone, Steven, Fu, Jingyuan, Magnani, Jared W., Marciante, Kristin D., Pfeufer, Arne, Gharib, Sina A., Teumer, Alexander, Li, Man, Bis, Joshua C., Rivadeneira, Fernando, Aspelund, Thor, Köttgen, Anna, Johnson, Toby, Rice, Kenneth, Sie, Mark P.S., Wang, Amanda Ying, Klopp, Norman, Fuchsberger, Christian, Wild, Sarah H., Leach, Irene Mateo, Estrada, Karol, Völker, Uwe, Wright, Alan F., Asselbergs, Folkert W., Qu, Jiaxiang, Chakravarti, Aravinda, Sinner, Moritz F., Kors, Jan A., Petersmann, Astrid, Harris, Tamara B., Soliman, Elsayed Z., Munroe, Patricia B., Psaty, Bruce M., Oostra, Ben A., Cupples, L. Adrienne, Perz, Siegfried, de Boer, Rudolf A., Uitterlinden, André G., Vözke, Henry, Spector, Timothy D., Liu, Fang-Yu, Boerwinkle, Eric, Dominiczak, Anna F., Rotter, Jerome I., van Herpen, Gé, Levy, Daniel, Wichmann, H.-Erich, van Gilst, Wiek H., Witteman, Jacqueline C.M., Kroemer, Heyo K., Kao, W.H. Linda, Heckbert, Susan R., Meitinger, Thomas, Hofman, Albert, Campbell, Harry, Folsom, Aaron R., van Veldhuisen, Dirk J., Schwienbacher, Christine, O’Donnell, Christopher J., Volpato, Claudia Beu, Caulfield, Mark J., Connell, John M., Launer, Lenore, Lu, Xiaowen, Franke, Lude, Fehrmann, Rudolf S.N., te Meerman, Gerard, Groen, Harry J.M., Weersma, Rinse K., van den Berg, Leonard H., Wijmenga, Cisca, Ophoff, Roel A., Navis, Gerjan, Rudan, Igor, Snieder, Harold, Wilson, James F., Pramstaller, Peter P., Siscovick, David S., Wang, Thomas J., Gudnason, Vilmundur, van Duijn, Cornelia M., Felix, Stephan B., Fishman, Glenn I., Jamshidi, Yalda, Stricker, Bruno H Ch, Samani, Nilesh J., Kääb, Stefan, Arking, Dan E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338195/
https://ncbi.nlm.nih.gov/pubmed/21076409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.716
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