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An Hsp90 modulator that exhibits a unique mechanistic profile
Described is the synthesis of two biotinylated derivatives of a cytotoxic macrocycle. Pull-down assays indicate that this macrocycle targets the N-middle domain of Hsp90. Untagged compound can effectively compete away tagged compound-Hsp90 protein complexes, confirming the binding specificity of the...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337333/ https://ncbi.nlm.nih.gov/pubmed/22480433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.03.012 |
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