OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

We have further defined mechanism(s) by which the drug OSU-03012 (OSU) kills tumor cells. OSU lethality was suppressed by knock down of PERK and enhanced by knock down of ATF6 and IRE1α. OSU treatment suppressed expression of the chaperone, BiP/GRP78, and did so through reduced stability of the prot...

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Bibliografske podrobnosti
Main Authors: Booth, Laurence, Cazanave, Sophie C, Hamed, Hossein A, Yacoub, Adly, Ogretmen, Besim, Chen, Ching-Shih, Grant, Steven, Dent, Paul
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336069/
https://ncbi.nlm.nih.gov/pubmed/22354011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.13.4.18877
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