17AAG and MEK1/2 inhibitors kill GI tumor cells via Ca(2+)-dependent suppression of GRP78/BiP and induction of ceramide and ROS

Benzer Materyaller

• MEK1/2 inhibitors and 17AAG synergize to kill human GI tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95
  Yazar:: Park, Margaret A., ve diğerleri
  Baskı/Yayın Bilgisi: (2008)
• OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing
  Yazar:: Booth, Laurence, ve diğerleri
  Baskı/Yayın Bilgisi: (2012)
• Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene.
  Yazar:: Ng, D T, ve diğerleri
  Baskı/Yayın Bilgisi: (1992)
• Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in GI tumor cells
  Yazar:: Park, Margaret A., ve diğerleri
  Baskı/Yayın Bilgisi: (2010)
• Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca2+ - de novo ceramide - PP2A - ROS dependent signaling pathway
  Yazar:: Park, Margaret A., ve diğerleri
  Baskı/Yayın Bilgisi: (2010)