OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

We have further defined mechanism(s) by which the drug OSU-03012 (OSU) kills tumor cells. OSU lethality was suppressed by knock down of PERK and enhanced by knock down of ATF6 and IRE1α. OSU treatment suppressed expression of the chaperone, BiP/GRP78, and did so through reduced stability of the prot...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Booth, Laurence, Cazanave, Sophie C, Hamed, Hossein A, Yacoub, Adly, Ogretmen, Besim, Chen, Ching-Shih, Grant, Steven, Dent, Paul
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Landes Bioscience 2012
विषय:
Research Paper
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336069/
https://ncbi.nlm.nih.gov/pubmed/22354011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.13.4.18877
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