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OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing
We have further defined mechanism(s) by which the drug OSU-03012 (OSU) kills tumor cells. OSU lethality was suppressed by knock down of PERK and enhanced by knock down of ATF6 and IRE1α. OSU treatment suppressed expression of the chaperone, BiP/GRP78, and did so through reduced stability of the prot...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3336069/ https://ncbi.nlm.nih.gov/pubmed/22354011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.13.4.18877 |
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