Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

We have previously demonstrated that enhanced aerobic glycolysis and/or autophagy in the tumor stroma supports epithelial cancer cell growth and aggressive behavior, via the secretion of high-energy metabolites. These nutrients include lactate and ketones, as well as chemical building blocks, such a...

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Hlavní autoři: Chiavarina, Barbara, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Witkiewicz, Agnieszka K, Birbe, Ruth C, Howell, Anthony, Pestell, Richard G, Smith, Johanna, Daniel, Rene, Sotgia, Federica, Lisanti, Michael P
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2011
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335944/
https://ncbi.nlm.nih.gov/pubmed/22236875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.12.18703
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