Metabolic reprogramming and two-compartment tumor metabolism: Opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells

Hypoxia-inducible factor (HIF) 1α and 2α are transcription factors responsible for the cellular response to hypoxia. The functional roles of HIF1α and HIF2α in cancer are distinct and vary among different tumor types. The aim of this study was to evaluate the compartment-specific role(s) of HIF1α an...

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Main Authors: Chiavarina, Barbara, Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Howell, Anthony, Tanowitz, Herbert B., Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466527/
https://ncbi.nlm.nih.gov/pubmed/22894905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21643
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