HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

Our recent studies have mechanistically implicated a loss of stromal Cav-1 expression and HIF1α-activation in driving the cancer-associated fibroblast phenotype, through the paracrine production of nutrients via autophagy and aerobic glycolysis. However, it remains unknown if HIF1α-activation is suf...

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Bibliografski detalji
Glavni autori: Chiavarina, Barbara, Whitaker-Menezes, Diana, Migneco, Gemma, Martinez-Outschoorn, Ubaldo E, Pavlides, Stephanos, Howell, Anthony, Tanowitz, Herbert B, Casimiro, Mathew C, Wang, Chenguang, Pestell, Richard G, Grieshaber, Philip, Caro, Jaime, Sotgia, Federica, Lisanti, Michael P
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2010
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047618/
https://ncbi.nlm.nih.gov/pubmed/20864819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.17.12908
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